Animal Models Core

part of the Genome Editing and Animal Models Facility (GEAM)

GEAM is a Shared Resource of the University of Wisconsin-Madison Carbone Cancer Center.

The Animal Models Core provides support for the generation of novel animal (mice, rats and swine) models using CRISPR or transgenic technology, cryopreservation, rederivation, and IVF recovery of rodent animal models. A full suite of services is available, including:

  • Generation of mouse, rat or swine CRISPR/Cas9 models
  • Cryopreservation of mouse and rat embryos and sperm
  • Rederivation of rodent animal models from off-campus sources
  • Generation of transgenic and ES cell targeted models
  • Reproductive assistance of rodent animals

After consultation with the investigator, CRISPR project design and reagent synthesis is completed. Reagents are injected into rodent embryos, and resultant pups are genotyped. The line can be returned to the investigator while also cryopreserved.

Lines can be recovered from cryopreserved sperm, embryos, or ES cells.

Click below for an online Bio-Tech Talk Presentation from April 16th, 2020:

“Being Ready for Mouse Research After COVID-19”
by Robert Taft, The Jackson Laboratory

UWBC Bio-Tech Talks