Kathy Krentz, Director, Animal Models Core
UW Biotechnology Center’s Animal Models and Advanced Genome Editing Cores Support Breakthrough Gene Therapy Research
UW-Madison researchers, led by Dr. Anjon Audhya, have made significant strides in gene therapy for motor neuron disease. A key component of this research was the utilization of a specific rat strain developed by the UW-Madison Biotechnology Center’s Animal Models and Advanced Genome Editing Cores. This innovative strain, described in a recent paper published in PNAS, enabled researchers to target and deliver healthy copies of the TFG gene directly to motor neurons, providing protection against the disease. This breakthrough showcases the invaluable contributions of the Animal Models Core at the UW Biotechnology Center to cutting-edge biomedical research.
Animal Models Core
Contact Information
- Kathy Krentz
Director
Room 3124
Biotechnology Center
425 Henry Mall Madison WI 53706
Submission Forms:
Animal Models Submission Form (Not CRISPR)
The Animal Models Core provides support for the generation of novel animal (mice, rats and swine) models using CRISPR or transgenic technology, cryopreservation, rederivation, and IVF recovery of rodent animal models. A full suite of services is available and not limited to:
- Generation of mouse, rat or swine CRISPR/Cas9 models
- Cryopreservation of mouse and rat embryos and sperm
- Rederivation of rodent animal models from off-campus sources
- Global importation of rodent models from international repositories
- Generation of transgenic and ES cell targeted models
- Reproductive assistance of rodent animals (breeding consultation, ovarian transplants, sperm analysis, fertility assessment)
The UWBC Animal Models Core accepts projects from all UW-Madison departments, the University of Wisconsin System, academic institutions in the US, and commercial/industry clients. Let us know how we can help you!